The Cowboys own an 18-game non-conference home win streak and have beaten the No. 19 Buffaloes five straight times heading into Saturday night's matchup between these unbeatens.
Wyoming (7-0) is off to its best start since going 11-0 to begin the 1987-88 season. Colorado is 6-0 for the first time since 1989, and is trying for its first 7-0 start since 1982-83.
The Cowboys haven't lost at home to a non-conference foe since a 68-62 defeat to Green Bay on Dec. 22, 2010, and the Buffaloes will be playing their first road game.
"Laramie, Wyoming is not an easy place to play," Colorado coach Tad Boyle said. "It will be like other teams that come here and play at 7,000 feet. They are going to have the advantage and the altitude, we are going to have to overcome that."
Wyoming won matchups between these teams in 1997, 1998, 2006 and 2007 before this series resumed last Dec. 9, with the Cowboys traveling to Boulder for a 65-54 victory.
"Wyoming will be a great test," said Buffaloes guard Spencer Dinwiddie, who scored a team-high 16 points in last season's meeting. "Wyoming is a team that came in here and beat us last year, they are a little bit different but we are going to even higher altitude and I heard they are pretty solid, so this should be a fun test for the team to get a true road game."
The Buffaloes felt fortunate after winning 85-80 in double overtime at home Tuesday over a Texas Southern team that entered with a 1-5 mark.
Colorado shot a season-low 39.0 percent. Dinwiddie scored a season-high 24 points while leading scorer Askia Booker had 15 on 4-of-15 shooting.
"There is no question that at the end of the game this will help us get better," Boyle said. "We needed maybe this to wake us up a little bit going into Wyoming."
Booker was a freshman reserve last season when he had nine points - close to his average of 9.1 - against Wyoming. He's averaging 16.8 points this season and was named tournament MVP in helping the Buffaloes win last month's Charleston Classic.
Martinez scored 17 points as Wyoming cruised to a 68-40 rout at UC Santa Barbara on Wednesday. The blowout caused Washington to finish with season lows in minutes (24) and points (nine).
"The whole crew really played well collectively at both ends of the floor tonight," coach Larry Shyatt told Wyoming's official website. "That's unique and doesn't always happen on the road or at home."
Sophomore starting guard Riley Grabau was limited to three minutes because of knee problems. Grabau's status for Saturday is unclear, although he may have incentive to play because he grew up in Boulder and was asked by Boyle to walk on at Colorado before Wyoming offered him a scholarship.