| Domingo, 5 de Abril |
| Hora (Este) | Visitante | Local | Lanzador
Visitante | Lanzador
Local | Estadio |
| 8:05 p.m. | Braves | Phillies | Atl: Derek Lowe | Phi: Brett Myers | Citizens Bank Park
Philadelphia, Pennsylvania |
| Lunes, 6 de Abril |
| Hora (Este) | Visitante | Local | Lanzador
Visitante | Lanzador
Local | Estadio |
| 1:10 p.m. | Mets | Reds | NYM: Johan Santana | Cin: Aaron Harang | Great American Ball Park
Cincinnati, Ohio |
| 2:05 p.m. | Rays | Red Sox | | Bos: Josh Beckett | Fenway Park
Boston, Massachusetts |
| 2:05 p.m. | Royals | White Sox | | CWS: Mark Buehrle | U.S. Cellular Field
Chicago, Illinois |
| 2:05 p.m. | Indians | Rangers | Cle: Cliff Lee | Tex: Kevin Millwood | Rangers Ballpark in Arlington
Arlington, Texas |
| 3:40 p.m. | Rockies | Diamondbacks | Col: Aaron Cook | Ari: Brandon Webb | Chase Field
Phoenix, Arizona |
| 4:05 p.m. | Yankees | Orioles | NYY: CC Sabathia | Bal: Jeremy Guthrie | Oriole Park at Camden Yards
Baltimore, Maryland |
| 4:10 p.m. | Nationals | Marlins | Was: John Lannan | Fla: Ricky Nolasco | Land Shark Stadium
Miami, Florida |
| 4:15 p.m. | Pirates | Cardinals | Pit: Paul Maholm | StL: Adam Wainwright | Busch Stadium
St. Louis, Missouri |
| 7:05 p.m. | Cubs | Astros | ChC: Carlos Zambrano | Hou: Roy Oswalt | Minute Maid Park
Houston, Texas |
| 7:05 p.m. | Dodgers | Padres | LAD: Hiroki Kuroda | SD: Jake Peavy | PETCO Park
San Diego, California |
| 7:15 p.m. | Tigers | Blue Jays | Det: Justin Verlander | Tor: Roy Halladay | Rogers Centre
Toronto, Ontario |
| 8:10 p.m. | Mariners | Twins | Sea: Felix Hernandez | Min: Francisco Liriano | Hubert H. Humphrey Metrodome
Minneapolis, Minnesota |
| 9:05 p.m. | Athletics | Angels | Oak: Dallas Braden | LAA: Joe Saunders | Angel Stadium of Anaheim
Anaheim, California |
| Martes, 7 de Abril |
| Hora (Este) | Visitante | Local | Lanzador
Visitante | Lanzador
Local | Estadio |
| 2:05 p.m. | Royals | White Sox | KC: Gil Meche | CWS: Mark Buehrle | U.S. Cellular Field
Chicago, Illinois |
| 4:05 p.m. | Rays | Red Sox | TB: James Shields | Bos: Josh Beckett | Fenway Park
Boston, Massachusetts |
| 4:05 p.m. | Brewers | Giants | Mil: Jeff Suppan | SF: Tim Lincecum | AT&T Park
San Francisco, California |
| 7:05 p.m. | Braves | Phillies | Atl: Jair Jurrjens | Phi: Jamie Moyer | Citizens Bank Park
Philadelphia, Pennsylvania |
| 7:07 p.m. | Tigers | Blue Jays | Det: Edwin Jackson | Tor: David Purcey | Rogers Centre
Toronto, Ontario |
| 7:10 p.m. | Nationals | Marlins | Was: Scott Olsen | Fla: Josh Johnson | Land Shark Stadium
Miami, Florida |
| 8:05 p.m. | Cubs | Astros | ChC: Ryan Dempster | Hou: Wandy Rodriguez | Minute Maid Park
Houston, Texas |
| 8:10 p.m. | Mariners | Twins | Sea: Erik Bedard | Min: Nick Blackburn | Hubert H. Humphrey Metrodome
Minneapolis, Minnesota |
| 8:15 p.m. | Pirates | Cardinals | Pit: Ian Snell | StL: Kyle Lohse | Busch Stadium
St. Louis, Missouri |
| 9:40 p.m. | Rockies | Diamondbacks | Col: Ubaldo Jimenez | Ari: Dan Haren | Chase Field
Phoenix, Arizona |
| 10:05 p.m. | Athletics | Angels | Oak: Trevor Cahill | LAA: Dustin Moseley | Angel Stadium of Anaheim
Anaheim, California |
| 10:05 p.m. | Dodgers | Padres | LAD: Randy Wolf | SD: Chris Young | PETCO Park
San Diego, California |
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