The right-hander will also seek to help the Giants end a four-game losing streak to the Milwaukee Brewers in the series opener at AT&T Park.
Gaudin (5-2, 2.64 ERA) is 3-1 with a 2.38 ERA in his last six starts but was tagged for six runs over 3 2-3 innings in an 8-3 loss to Cincinnati on July 24. He bounced back from that difficult outing by giving up just a solo homer and three singles over seven innings in a 9-2 victory in Philadelphia on Wednesday.
Gaudin has allowed one or no runs in five of his last six outings, and he'll next try to aid the Giants' attempt to avoid a third consecutive loss and their eighth in nine home games. San Francisco (49-61) won three straight before back-to-back defeats in Tampa Bay over the weekend and couldn't hold on to a one-run lead in a 4-3 loss Sunday.
"It is (disappointing) to come in here and lose two tough ones like this, especially with the little things that got us," manager Bruce Bochy said. "We had a chance to add on runs a couple times. We couldn't do it, and those things usually come back to haunt you."
Before their recent win streak, the Giants had dropped eight of nine, and Bochy is going to insert either Hunter Pence or Marco Scutaro at the top of the lineup to spark his club.
"We're not getting any production from our leadoff hitters," said Bochy, whose leadoff hitters have a cumulative .247 batting average. "We're definitely going through a tough time and we're going to change things up here a little bit. We've talked about Pence going there. (Pence) says he's done it before, and Scutaro has experience there, and he's done a good job of it."
San Francisco will try to end its brief skid and win for the sixth time in eight home games against Milwaukee (47-64). The Brewers, though, swept the only series between the clubs this season April 16-18 and head into this matchup having won five of their last eight road games.
Milwaukee snapped a three-game losing streak Sunday by rallying for an 8-5 victory against visiting Washington. After falling behind 4-1 in the top of the sixth, the Brewers scored five times in the bottom of the frame.
Jeff Bianchi drove in the tiebreaking runs with a bloop single and has nine of his 16 RBIs in his last eight games.
"One inning, sometimes it's just one big at-bat - you don't know what's going to turn things around," manager Ron Roenicke said. "We got some breaks."
Tyler Thornburg (1-0, 2.22) will try to keep Milwaukee heading in the right direction with another strong outing. The right-hander pitched six scoreless innings in his first start this season and fourth in the majors but did not get a decision in a 3-2 win at the Chicago Cubs on Tuesday.
Thornburg, filling in for an injured Yovani Gallardo, will face San Francisco for the first time and Gaudin will make his first start against Milwaukee since July 31, 2009. Gaudin did not get a decision in an 11-7 win for San Diego after giving up seven runs - three earned - in just 1 2-3 innings.