The right-hander looks to deliver one of his own when Cincinnati tries to win its seventh straight over the Colorado Rockies on Tuesday night.
With Jay Bruce hitting a two-run eighth-inning homer and Bronson Arroyo pitching eight innings, the Reds (36-22) posted a 3-0 victory in Monday's series opener. Back from a 2-3 road trip, Cincinnati won for the eighth time in nine tries at Great American Ball Park to improve to a major league-best 21-7 at home.
Colorado had scored seven runs in each of the previous two games - both wins - to move past the Reds with an NL-leading 275 runs.
"That's a tough ballclub to shut out," manager Dusty Baker said.
Reds starters have posted a 0.64 ERA as the team has blanked three of four opponents since Bailey's last outing, a 7-1 loss at Cleveland on Thursday. He surrendered a season high-tying seven runs, all with two outs in the fourth inning, before getting pulled.
Bailey had gone 2-0 with a 1.64 ERA in his previous three outings. He's 2-0 with a 2.32 ERA in his five home starts, with Cincinnati winning each of those contests.
However, Bailey has gone 1-2 with a 5.47 ERA in five starts against Colorado, and his two strong starts versus the Rockies have surprisingly come at hitter-friendly Coors Field. Bailey has gone 0-2 with a 9.69 ERA in three home outings against them.
The Rockies (30-28), losers of five of six in Cincinnati, will send Juan Nicasio (4-2, 4.79) to the mound for his first appearance against the Reds. The right-hander is looking for a better effort after surrendering a season high-tying five runs in five innings of a 7-5 loss to Houston on Thursday.
Nicasio had surrendered two runs in 11 innings in his previous two starts.
Reds second baseman Brandon Phillips has missed the last two games with a left forearm contusion, and he's not expected back during this three-game set. Cesar Izturis, who went 0 for 4 in the opener, or Jack Hannahan will likely get the start Tuesday.
Joey Votto will try to start a new hitting streak against the Rockies after an 0-for-4 effort with two strikeouts Monday ended an eight-game run.
Shortstop Zack Cozart is batting .364 during an eight-game hitting streak. He's hit .391 in his last 11 games to raise his average 40 points to .246.
Colorado's Michael Cuddyer is batting .448 with two home runs and seven RBIs during a seven-game hitting streak.
Teammate Troy Tulowitzki is 5 for 9 off Bailey.
Rookie third baseman Nolan Arenado continued to struggle Monday, going 0 for 4. He's 3 for 24 in his past six games.
"I'm not too concerned about Nolan, because he's going to hit up here," manager Walt Weiss told the team's official website. "With young players, you want to make sure they're OK and not getting too beat up by the game mentally. He's barreled up enough balls in a short time up here to say he can hit up here."
Despite the Rockies' gaudy season run total, they've scored seven times in their last four road games and have gone 1-4 in their last five away from home.