National Football League

NFL Week 11 top plays: 49ers rout Cardinals in Mexico City

Updated Nov. 21, 2022 11:41 p.m. ET

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Week 11 of the NFL season closed with the San Francisco 49ers blitzing the Arizona Cardinals in an all-important NFC West tilt on Monday Night Football.

The domination went down at Mexico City's Estadio Azteca in the fifth and final game of the 2022 International Series. 

Kyler Murray was inactive, so Colt McCoy made his second start for the Cardinals.

San Francisco 49ers 38, Arizona Cardinals 10

Hear the roar

The crowd was loud in the early going, cheering for "defense" and roaring as McCoy tried to hit DeAndre Hopkins in the end zone but couldn't connect. The Cardinals settled for a 46-yard field goal and the 3-0 lead.

Knowledgeable fans

The fans in Mexico City know good football, sending up loud cheers when the 49ers downed this punt at the 4-yard line.

Aiyuk of the tiger

The 49ers promptly marched down the field on their third drive, capped by a touchdown pass from Jimmy Garoppolo to Brandon Aiyuk. 

Turnover tip

A McCoy pass bounced off the hands of Cards RB James Conner and into those of 49ers DB Jimmie Ward, putting the Niners in Arizona territory.

Made you look

Jimmy G had the Cardinals defense thinking he would scamper for a first down when he and George Kittle improvised for a 39-yard TD. That gave San Francisco a 14-3 advantage.

Third-and-Dortch

Following two third-down conversions from wideout Greg Dortch, including a 47-yarder, Conner rammed it in to cut the Cards' deficit to four.

Gould touch

An initially promising 49ers drive stalled just outside the red zone, setting up a 39-yard field goal from Robbie Gould. San Francisco took a 17-10 lead into the break. 

19 problems

Deebo Samuel. That's the caption. 24-10 is the score.

Twice as nice

Jimmy G and Aiyuk have hooked up two times Monday. Both have resulted in touchdowns.

YAC YAC YAC!

The blowout is in full effect, as a short Garoppolo pass turned into another Kittle TD. The 38-10 score proved to be the final tally.

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National Football League

San Francisco 49ers

Arizona Cardinals

NFL - San Francisco 49ers vs. Arizona Cardinals - 11/22/2022

Kyler Murray

Jimmy Garoppolo

Colt McCoy