Astros vs. Cubs Prediction, Odds, Picks - April 25

Updated Apr. 25, 2024 2:00 p.m. ET

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Kyle Tucker and the Houston Astros will try to out-hit Mike Tauchman and the Chicago Cubs at Wrigley Field on Thursday at 2:20 PM ET. The Astros are -143 moneyline favorites in this matchup with the Cubs (+121). Houston is the run-line favorite (-1.5). The total is 7.5 runs for the matchup (with +101 odds on the over and -121 odds to go under).

Here's everything you need from a betting perspective on the Astros-Cubs game, regarding the run line, moneyline and total, plus expert picks.

Astros vs. Cubs Highlights | MLB on FOX

Check out the greatest plays in this matchup between the Houston Astros and the Chicago Cubs.

Astros vs. Cubs Game Information & Odds

• When: Thursday, April 25, 2024 at 2:20 PM ET
• Where: Wrigley Field in Chicago, Illinois
• How to Watch on TV: SCHN

Astros vs. Cubs Prediction

• Score Prediction: Cubs 5, Astros 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 58%, Cubs 42%

Astros vs. Cubs Betting Insights

• This season, the Astros have won five out of the 20 games, or 25%, in which they've been favored.
• Houston has a record of 3-4 when favored by -143 or more by sportsbooks this season.
• Oddsmakers have implied with the moneyline set for this matchup that the Astros have a 58.8% chance to win.
• The Cubs have been underdogs in 16 games this season and have come away with the win nine times (56.2%) in those contests.
• This season, Chicago has come away with a win two times in four chances when named as an underdog of at least +121 or longer on the moneyline.
• The Cubs have an implied victory probability of 45.2% according to the moneyline set for this matchup.

FINAL

HOU 1 · CHC 3

MLB

RUN LINE

TO WIN

TOTAL

Houston Astros

HOU

-1.5

-146

o7.5

Chicago Cubs

CHC

+1.5

+123

u7.5

Astros Recent Betting Performance

• The Astros have a 3-4 record over the seven games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to hit the over two times.
• The Astros have a 4-6-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Tucker has accumulated a team-best 17 runs batted in.
• Of all hitters in the majors, Tucker's home run total places him 24th, and his RBI tally ranks him 19th.
• Tucker carries a two-game hitting streak into this matchup. During his last five outings he is hitting .368 with two doubles, three walks and two RBI.
• Jose Altuve's six home runs and .350 batting average both pace his team.
• Altuve ranks ninth in homers and 156th in RBI in the major leagues.
• Altuve enters this game looking for his third game in a row with a hit. In his last five games he is hitting .217 with a home run and an RBI.
• Yordan Alvarez is hitting .273 with three doubles, five home runs and 10 walks.
• Jeremy Pena is hitting .337 with five doubles, two home runs and three walks.

Astros Team Props

Learn more about this Astros vs. Cubs matchup on Fox Sports.

Cubs Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Cubs have a record of 5-1.
• When it comes to hitting the over, the Cubs and their opponents are 3-7-0 in their last 10 games with a total.
• The Cubs have eight wins against the spread in their last 10 chances.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner has six doubles, a triple and 10 walks while hitting .271.
• Hoerner's home run total puts him 283rd in the big leagues, and he ranks 179th in RBI.
• Michael Busch has hit six home runs while hitting .280. Both high-water marks on his team.
• Busch ranks ninth in home runs and 24th in RBI among all MLB hitters this season.
• Christopher Morel has two doubles, a triple, three home runs and 11 walks while hitting .205.
• Ian Happ is hitting .232 with five doubles, a triple, a home run and 14 walks.

Cubs Team Props

Astros vs. Cubs Highlights | MLB on FOX

Check out the greatest plays in this matchup between the Houston Astros and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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MLB - Houston Astros vs. Chicago Cubs - 04/25/2024