Santander is out of the lineup Sunday against the Mariners due to soreness and swelling in his left knee, Andy Kostka of TheBaltimoreBanner.com reports.
Keller (0-2) took the loss Saturday as the White Sox were downed 6-1 by the Yankees, coughing up six runs (five earned) on seven hits -- including four home runs -- and a walk over four-plus innings. He struck out four.